What is sarcomatoid urothelial carcinoma?

What is sarcomatoid urothelial carcinoma?

Sarcomatoid urothelial carcinoma is a very dangerous malignant tumour derived from the epithelium; its cells which are sarcomatoid differentiation can occur in any cancerous parts and more common in the respiratory system [1]. Primary sarcomatoid carcinoma of the ureter is extremely rare in clinical practice.

How is sarcomatoid carcinoma diagnosed?

Your provider can determine if a tumor is sarcomatoid carcinoma based on how its cells look. They’ll also classify it into subtypes (for example, pleomorphic carcinoma, spindle-cell carcinoma, etc.) Immunohistochemistry: Immunohistochemistry tests for substances, called antigens, associated with specific cell types.

What are the symptoms of sarcomatoid carcinoma?


  • A lump that can be felt through the skin that may or may not be painful.
  • Bone pain.
  • A broken bone that happens unexpectedly, such as with a minor injury or no injury at all.
  • Abdominal pain.
  • Weight loss.

What is urothelial carcinoma of kidney?

Renal transitional cell carcinoma (TCC), or renal urothelial carcinoma (UC), is a malignant tumor arising from the transitional (urothelial) epithelial cells that line the urinary tract from the renal calyces to the ureteral orifice (see the image below). UC is the most common tumor of the renal pelvis.

Can you survive sarcomatoid carcinoma?

Sarcomatoid carcinoma is very aggressive, with an overall 5-year survival rate of approximately 20% [2]. Limited data has shown that most cases of sarcomatoid carcinomas occur with advanced local disease and metastasis.

What causes sarcomatoid carcinoma?

DNA mutations in soft tissue sarcoma are common. But they’re usually acquired during life rather than having been inherited before birth. Acquired mutations may result from exposure to radiation or cancer-causing chemicals. In most sarcomas, they occur for no apparent reason.

Is there a cure for sarcomatoid carcinoma?

Abstract. Pulmonary sarcomatoid carcinoma (PSC) is a pathological subtype of non-small-cell lung cancer. Although the incidence of PSC in lung cancer is very low, it is an aggressive cancer, leading to a poor prognosis. Currently, there is no standard treatment for advanced PSC.

Can urothelial carcinoma be cured?

Follow-up and outlook after treatment

These cancers can be cured with treatment. During long-term follow-up care, more superficial cancers are often found in the bladder or in other parts of the urinary system. Although these new cancers do need to be treated, they rarely are deeply invasive or life threatening.

What is the life expectancy for urothelial carcinoma?

5-year relative survival rates for bladder cancer

SEER Stage 5-year Relative Survival Rate
In situ alone Localized 96% 70%
Regional 38%
Distant 6%
All SEER stages combined 77%

What is the meaning of sarcomatoid?

Sarcomatoid is a word used to describe cancer cells that look similar to the cells found in a type of cancer called sarcoma. However, sarcomatoid cells are not true sarcoma cells and the tumour is usually another type of cancer called a carcinoma.

How aggressive is urothelial carcinoma?

Muscle-invasive urothelial carcinomas are highly aggressive compared to cancers of the upper urinary tract, carrying a five-year disease-specific survival rate of <50% in pT2/pT3 disease, and this survival rate drops below 10% in pT4 cancer.

What stage is high grade urothelial carcinoma?

Grade 3. The cancer cells look very abnormal. They are called high grade or poorly differentiated. They grow more quickly and are more likely to come back after treatment or spread into the deeper (muscle) layer of the bladder.

Can high grade urothelial carcinoma be cured?

High-grade T1 (T1HG) bladder cancer (BCa) has a very high likelihood of disease recurrence and progression to muscle invasion. Radical cystectomy is considered the best chance at cure, albeit with a high risk of morbidity, and is overtreatment for some patients.

What is the survival rate of urothelial carcinoma?

Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed.

5-year relative survival rates for bladder cancer.

SEER Stage 5-year Relative Survival Rate
All SEER stages combined 77%