What is fondaparinux 7.5 mg used for?
Fondaparinux is used to treat serious blood clots in the legs and/or lungs. It is usually used with another “blood thinner” medication (warfarin). If untreated, blood clots can travel to the lungs, heart, or brain, causing serious (possibly fatal) breathing problems, heart attack, or stroke.
Can you give fondaparinux in HIT?
For patients with HIT, it is critical to initiate nonheparin anticoagulation in order to prevent both thrombotic and bleeding complications. Use of fondaparinux, a selective factor Xa inhibitor, is common for treatment of HIT, albeit without Food and Drug Administration approval.
What anticoagulant is used for HIT?
A direct thrombin inhibitor, such as lepirudin, danaparoid or argatroban, is considered the agent of choice for treatment of HIT. Warfarin should not be used until the platelet count has recovered.
Why fondaparinux is safe in HIT?
Patients with HIT have antibodies that react with a complex of platelet factor 4 and heparin, but these antibodies appear to have minimal or no reactivity with fondaparinux.
When do you give fondaparinux?
The recommended dose of fondaparinux is 2.5 mg once daily administered post-operatively by subcutaneous injection. The initial dose should be given 6 hours following surgical closure provided that haemostasis has been established.
Can you use enoxaparin in HIT?
Patients with HIT may safely receive enoxaparin if their plasma does not aggregate platelets in the presence of enoxaparin.
Does fondaparinux cause heparin induced thrombocytopenia?
It seems plausible that anti-PF4/heparin antibodies generated through previous exposure to fondaparinux resulted in a clinical syndrome of HIT. The rapidity of thrombocytopenia with thrombosis suggests an anamnestic response to preformed anti-PF4/heparin antibodies upon exposure to enoxaparin.
Do you give fondaparinux in stemi?
In conclusion, fondaparinux significantly reduced mortality without increasing severe bleeding in patients with STEMI. Overall, the data from the OASIS studies showed that fondaparinux 2.5 mg may represent a new anticoagulant standard in patients with acute coronary syndromes.
Do you give platelets for HIT?
Platelet transfusions should be avoided in HIT, as they may increase the thrombogenic effect.
Can you use Lovenox in HIT?
Can you get HIT with LMWH?
Abstract. Heparin-induced thrombocytopenia (HIT) is an uncommon but potentially devastating complication of anticoagulation with unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH).
Why is argatroban used in HIT?
Argatroban is rapidly acting and has been shown to significantly reduce the risk of death or new thrombosis [Lewis et al. 2001]. Treatment of HIT with argatroban successfully lowers mortality rates from thrombosis without increased bleeding risk [Lewis et al. 2001].
Where do you inject Fondaparinux?
Fondaparinux injection comes as a solution (liquid) to be injected subcutaneously (just under the skin) in the lower stomach area. It is usually given one time a day for 5 to 9 days or sometimes for up to about 1 month.
What is the recommended dose of Arixtra for hip fracture treatment?
In patients undergoing hip fracture, hip replacement, or knee replacement surgery, the recommended dose of ARIXTRA is 2.5 mg administered by subcutaneous injection once daily after hemostasis has been established.
How is Arixtra administered?
ARIXTRA is administered by subcutaneous injection. It must not be administered by intramuscular injection. ARIXTRA is intended for use under a physician’s guidance. Patients may self-inject only if their physician determines that it is appropriate and the patients are trained in subcutaneous injection techniques.
How much Arixtra should I take for DVT?
In patients with acute symptomatic DVT and in patients with acute symptomatic PE, the recommended dose of ARIXTRA is 5 mg (body weight <50 kg), 7.5 mg (body weight 50 to 100 kg), or 10 mg (body weight >100 kg) by subcutaneous injection once daily (ARIXTRA treatment regimen).
What is the duration of Arixtra therapy after surgery for ulcerative colitis?
Administration of ARIXTRA earlier than 6 hours after surgery increases the risk of major bleeding. The usual duration of therapy is 5 to 9 days; up to 11 days of therapy was administered in clinical trials.