What does it mean for a drug to be neuroprotective?
Neuroprotective agents are medications that can alter the course of metabolic events after the onset of ischemia and therefore have the potential to reduce stroke damage.
Is propofol neuroprotective?
Propofol is neuroprotective when administered immediately after stroke. The therapeutic window, duration of administration, and antioxidant mechanisms of propofol in neuroprotection are not known. The effects of propofol after stroke were examined in the conscious animal.
Is etomidate neuroprotective?
Some preclinical studies have demonstrated a neuroprotective effect of etomidate through a depression of cerebral metabolism, the inhibition of postischemic hyperemia, and attenuation of vascular-mediated inflammation [50–54].
What are neuroprotective benefits?
Neuroprotection aims to: limit nerve death after a CNS injury. protect the CNS from premature degeneration and other causes of nerve cell death.
Is nicotine a neuroprotective?
In addition to a potential neuroprotective action, nicotine also has anti-depressant properties and improves attention/cognition.
Is propofol a barbiturate?
Propofol is a non-barbiturate sedative, used in hospital settings by trained anesthetists for the induction, maintenance of general anesthesia, and sedation of ventilated adults receiving intensive care, for a period of up to 72 hours.
Is caffeine neuroprotective?
Abstract. Epidemiological studies suggest that both caffeinated coffee and decaffeinated coffee are neuroprotective. Data obtained from in vitro, in vivo, and human clinical trials have indicated that coffee exhibits protective effects against Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.
Is CBD neuroprotective?
At concentrations between 1 and 10 µm, CBD has also been reported to be neuroprotective, to reduce signs of oxidative stress, to modulate cytokine release and to increase calcium release from neuronal and glial intracellular stores (reviewed in ), and at 15 µM to induce mRNA expression of several phosphatases in …
What part of the brain does propofol affect?
The findings from the present study show that propofol induces concentration-dependent effects in the medial thalamus, cuneus, precuneus, and posterior cingulate and orbito-frontal cortices.
Does propofol cause cerebral vasoconstriction?
Propofol produces cerebral vasoconstriction indirectly by reducing cerebral metabolism. 17In dogs, propofol has been shown to decrease EEG activity and cerebral metabolism associated with a decrease in CBF.
Does propofol decrease ICP?
Propofol, a short-term acting sedative, can reduce the cerebral blood flow, ICP, and cerebral metabolic rate of oxygen (CMRO2).
Does propofol increase cerebral blood flow?
In young healthy adults, propofol anaesthesia, with limited reduction in blood pressure, decreases cerebral blood flow by approximately 50% by a decrease in neuronal activity.
Which anesthetics have neuroprotective properties?
Recent findings: Although a growing body of preclinical literature suggests that anesthetic agents such as barbiturates, volatile anesthetics, and propofol might have neuroprotective properties, clinical evidence of long-term benefit is lacking. Magnesium shows promise, although timing and dosing require clarification.
What is the meaning of neuroprotective?
Definition of neuroprotective : serving to protect neurons from injury or degeneration neuroprotective drugs : serving to protect nerve cells from injury or degeneration Neuroprotective strategies involve interfering with the ischemic cascade, thereby prolonging and substantially reducing stroke size.
What is the role of neuroprotective strategies in stroke prevention?
: serving to protect nerve cells from injury or degeneration Neuroprotective strategies involve interfering with the ischemic cascade, thereby prolonging and substantially reducing stroke size.
Is erythropoietin neuroprotective?
Despite some early promise, there is no strong evidence that erythropoietin is neuroprotective. Remote ischemic preconditioning is the subject of intense study. It is noninvasive, cheap, and reasonably well tolerated and shows promise as a preconditioning neuroprotective intervention.