Is TNK same as tPA?

In MI use, tNK is equivalent to tPA in terms of mortality, more potent in a patient with longer duration of MI and has a reduced rate of major bleeds. tNK has been trialed in more than 27,000 patients worldwide, she continued.

Is TNKase a tPA?

TNKase® (Tenecteplase) is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese Hamster Ovary cells).

What is the difference between tPA and tenecteplase?

Tenecteplase is a modified recombinant tissue plasminogen activator molecule (tPA) engineered to improve efficacy through increased affinity binding to fibrin, greater resistance to inactivation by plasminogen activator inhibitor-1, no procoagulant effects, and longer free plasma half-life [3].

What is TNK in cardiology?

Background—Bolus thrombolytic therapy is a simplified means of administering thrombolysis that facilitates rapid time to treatment. TNK-tissue plasminogen activator (TNK-tPA) is a highly fibrin-specific single-bolus thrombolytic agent.

What is TNK used for?

What is this medicine? TENECTEPLASE (TEN neck te place) is used to dissolve blood clots that form in certain blood vessels. This medicine is used when a blood clot in a heart artery causes a heart attack. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

How do you administer TNK?

INJECT entire contents (10 mL) into the TNKase vial, directing the diluent into the powder. Slight foaming upon reconstitution is not unusual; any large bubbles will dissipate if the product is allowed to stand undisturbed for several minutes. GENTLY SWIRL until contents are completely dissolved. DO NOT SHAKE.

Is Cathflo a tPA?

Cathflo® Activase® (Alteplase) is a tissue plasminogen activator (tPA) produced by recombinant DNA technology. It is a sterile, purified glycoprotein of 527 amino acids.

Is tenecteplase better than alteplase?

While not FDA-approved for acute stroke, tenecteplase has theoretical advantages over alteplase as it has greater fibrin specificity and has a longer half-life than alteplase. It is the preferred thrombolytic agent for ST-elevation myocardial infarction in the United States.

When should I give TNK?

Currently, TNK is only given to patients from 0 to 4.5 hours after onset of ischemic stroke symptoms. That may change, however, if data from clinical trials on an extended window or use in other populations are positive.

How much does TNKase cost?

The cost for TNKase intravenous powder for injection 50 mg is around $7,305 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

What is tPA for PICC line?

Purpose. To restore patency of clotted peripherally inserted central catheter (PICC) via installation of a thrombolytic agent (e.g. t-PA, Alteplase®). Alteplase is a commercially available thrombolytic agent that is approved for the use of blood clot breakdown.

Is tPA and alteplase the same?

Known by the generic name alteplase and marketed as Activase® (Genentech), tPA is given to patients through an IV in the arm, and it works by dissolving blood clots that block blood flow to the brain.

Why is alteplase used more than tenecteplase?

Alteplase remains the only FDA-approved thrombolytic for acute ischemic stroke. Tenecteplase, a modified tissue plasminogen activator, binds more selectively and has a longer half-life that allows it to be administered as a single bolus rather than the bolus and continuous infusion required for alteplase.

Is TNK approved for stroke?

To date, the only scientifically-proven and FDA-approved treatment for acute stroke is the clot-busting drug, tissue plasminogen activator (tPA). A newer clot-busting drug, tenecteplase (TNK), has chemical properties that make it a potentially safer and more effective drug for treating stroke.

Do you give heparin with TNKase?

In conclusion, ASSENT-3 and ENTIRE-TIMI 23 showed that a much simpler thrombolytic regimen is feasible, permitting bolus administration of both TNKase and of adjunctive low-molecular-weight heparin.

Is TNK weight based?

TNKase® (Tenecteplase) is for intravenous administration only. The recommended total dose should not exceed 50 mg and is based upon patient weight. A single bolus dose should be administered over 5 seconds based on patient weight.

Is TNKase approved for stroke?

Both Retavase and TNKase are only indicated for the management of acute myocardial infarction, and are not FDA approved for acute ischemic stroke or pulmonary embolism.

When do we use tPA?

A tPA is a drug used to break up a blood clot and restore blood flow to the brain. A tPA can only be administered within a few hours after stroke symptoms appear, so it is extremely important to call 911 at the first sign of a stroke.

What is the advantage of tenecteplase versus alteplase for drip and ship stroke patients?

The single-bolus administration of tenecteplase vs. an hour-long alteplase infusion is a major practical advantage, particularly in “drip and ship” patients with basilar artery occlusion who are being transported between hospitals. Other practical advantages include its reduced cost compared to alteplase.