How do I reconstitute VELETRI?

How do I reconstitute VELETRI?

Reconstitute VELETRI only as directed using Sterile Water for Injection, USP, or Sodium Chloride 0.9% Injection, USP. Do not mix VELETRI with any other parenteral medications or solutions prior to or during administration. Each vial is for single use only; discard any unused solution.

How do you administer VELETRI?

VELETRI, once prepared as directed [see Reconstitution (2.4)], is administered by continuous intravenous infusion via a central venous catheter using an ambulatory infusion pump. During initiation of treatment, VELETRI may be administered peripherally. Infusion sets with an in-line 0.22 micron filter should be used.

How do you change syringes in VELETRI?

Remove the empty syringe by unscrewing it. Next, remove the needle from the syringe containing VELETRI® (epoprostenol) for Injection. Attach the syringe to the tubing on the medication cassette. Unclamp the tubing and inject the drug into the medication cassette.

Does VELETRI require ice packs?

You may administer VELETRI without ice packs and remain on the same 24-hour cassette. You can store a backup cassette for 24 hours at room temperature (77°F/25°C) without ice packs.

How do you dilute Flolan?

Flolan must not be administered with other parenteral solutions or medications when used for pulmonary arterial hypertension. To dilute the concentrated solution, draw it up into a larger syringe and then attach the sterile filter provided to the syringe.

How often is VELETRI given?

Prepare VELETRI® (epoprostenol) for Injection for immediate use, OR prepare up to 8 fully diluted cassettes once weekly and refrigerate (36° to 46°F/2° to 8°C) for up to 8 days, for use at room temperature.

Are VELETRI and Flolan interchangeable?

Veletri (Epoprostenol) a continuous infusion used to treat PH. Veletri is the newest form of Epoprostenol. It is the same medication as Flolan but is stable at room temperature. It is infused continuously through a central line and is dispensed by a specialty pharmacy.

What happens if VELETRI stops?

Symptoms of suddenly stopping VELETRI include dizziness, weakness and difficulty breathing. As VELETRI has vasodilatory action, overdose may lead to low blood pressure, loss of consciousness, nausea, diarrhoea, vomiting, facial flushing, headache and fast heart beat.

Does VELETRI need to be refrigerated?

Prepare VELETRI for immediate use, OR prepare up to 8 fully diluted cassettes once weekly and refrigerate (36° to 46°F/2° to 8°C) for up to 8 days, for use at room temperature.

How long does it take for VELETRI to work?

In 8- and 12-week studies of epoprostenol therapy, people showed improvements in their ability to exercise (measured by how far they could walk in 6 minutes); some even showed improvement in as early as 1 week. There was also a reduction in symptoms, such as shortness of breath and fatigue.

What is the difference between Flolan and VELETRI?

Veletri is the newest form of Epoprostenol. It is the same medication as Flolan but is stable at room temperature. It is infused continuously through a central line and is dispensed by a specialty pharmacy. Please see the above information under Flolan for more information.

What is the half life of VELETRI?

Interruption of therapy administration may be life threatening because VELETRI has a half-life of approximately 6 minutes—meaning, within 6 minutes after the drug is absorbed, half the drug has already been used by the body or degraded. Because of this, it is necessary for VELETRI to be continuously infused.

What happens when you stop VELETRI?

It should not be stopped suddenly. Symptoms of suddenly stopping VELETRI include dizziness, weakness and difficulty breathing. As VELETRI has vasodilatory action, overdose may lead to low blood pressure, loss of consciousness, nausea, diarrhoea, vomiting, facial flushing, headache and fast heart beat.

What is the difference between Veletri and Flolan?

How long is Veletri good for?

8-day storage and once-weekly preparation

Prepare VELETRI for immediate use, OR prepare up to 8 fully diluted cassettes once weekly and refrigerate (36° to 46°F/2° to 8°C) for up to 8 days, for use at room temperature.

Is Veletri a vasopressor?

VELETRI is a potent pulmonary and systemic vasodilator. Initiate VELETRI in a setting with adequate personnel and equipment for physiologic monitoring and emergency care. During dose initiation, asymptomatic increases in pulmonary artery pressure coincident with increases in cardiac output occurred rarely.

Are Veletri and Flolan interchangeable?

How long does VELETRI take to work?

What is the half-life of VELETRI?

How does VELETRI affect blood pressure?

The cause of PAH is not known however there are a number of diseases such as scleroderma that are associated with PAH. VELETRI belongs to a group of medicines called prostaglandins. VELETRI works by widening the blood vessels in the lungs and so lowering the blood pressure in your lungs (known as a vasodilator action).

What are the side effects of VELETRI?

Side Effects Associated With VELETRI® (epoprostenol) for…

  • Flushing.
  • Headache.
  • Nausea/vomiting.
  • Low blood pressure.
  • Anxiety/nervousness.
  • Chest pain.
  • Dizziness.
  • Slow heartbeat.

Does VELETRI affect blood pressure?