How do you make buccal tablets?
Buccal tablets were prepared by direct compression method. Tablet ingredients were screened through a 0.150-mm sieve before mixing to achieve a uniform particle size distribution. Then, 1 mg of RIS and required amounts of polymer and LM were weighed carefully and mixed with a cubic mixer for 15 minutes.
How do you make mucoadhesive tablets?
Preparation of mucoadhesive tablets Mucoadhesive tablets were prepared by conventional wet granulation. The powder mix was granulated with 5% w/w PVP‐K30 in isopropyl alcohol. The wet mass was passed through sieve # 16 and the granules were dried at 60°C for 1 hrs in a hot air oven.
What is formulation consideration of buccal delivery system?
To fulfill the therapeutic requirements, formulations for buccal administration should contain: mucoadhesive agents, to maintain an intimate and prolonged contact of the formulation with the absorption site; penetration enhancers, to improve drug permeation across mucosa (transmucosal delivery) or into deepest layers …
What is the disintegration time of coated tablets?
COATED TABLETS Introduce one tablet into each of the six tubes, add disc to each tube, and operate the apparatus, using water as the immersion fluid. Unless otherwise stated in the individual monograph film-coated tablets disintegrate within 30 minutes and other coated tablets disintegrate within 60 minutes.
Are buccal and sublingual the same?
Sublingual administration involves placing a drug under the tongue and buccal administration involves placing a drug between the gums and cheek.
What is used in mucoadhesive tablets?
This project was aimed to formulate and characterize mucoadhesive buccal tablets of aceclofenac, utilizing different proportions of three polymers carbopol 934, hydroxypropyl methylcellulose, and sodium carboxymethylcellulose. Twelve batches of buccoadhesive aceclofenac were prepared by the direct compression method.
What is buccal bioavailability?
Buccal administration may provide better bioavailability of some drugs and a more rapid onset of action compared to oral administration because the medication does not pass through the digestive system and thereby avoids first pass metabolism.
What are the stages of Mucoadhesion?
The mechanism by which mucoadhesion takes place has been said to have two stages, the contact (wetting) stage followed by the consolidation stage (the establishment of the adhesive interactions). The relative importance of each stage will depend on the individual application.
What is bioadhesive drug delivery system?
The term bioadhesive describes materials that bind to biological substrates, such as mucosal membranes and in bioadhesive drug delivery systems, the term bioadhesion is used to describe the bonding or adhesion between a synthetic or natural polymer and soft tissues such as epithelial cells.
What are the stages of mucoadhesion?
What is buccal tablet?
Buccal Medicines: Giving Buccal Medicines. A buccal medicine is a medicine given between the gums and the inner lining of the mouth cheek. This area is called the buccal pouch. Medicine is usually given in the buccal area when it is needed to take effect quickly or when the child is not conscious.
Which polymers is used in mucoadhesive drug delivery system?
The various mucoadhesive polymers which have been used for the development of oral delivery systems include chitosan, poly(acrylic acid), alginate, poly(methacrylic acid) and sodium carboxymethyl cel- lulose [62].
What is maximum duration of action of buccal delivery?
Nevertheless, the maximum duration for buccal drug delivery is usually limited to approximately 4–6 h, since meal intake and/or drinking may require dosage form removal. Pathological aspects: Some diseases or treatments may also influence the secretion and properties of the mucus, as well as the saliva.
Is buccal local or systemic?
Buccal administration is intended for delivering drugs within/through the buccal mucosa in order to achieve a local or systemic effect. This route is particularly attractive since substances absorbed through the buccal mucosa bypass gastrointestinal enzymatic degradation and the hepatic first-pass effect.
Is there a PhD thesis on bioadhesive drug delivery system?
It is certified that PhD Thesis titled Formulation Development and Evaluation of Bioadhesive Drug Delivery System containing selected Phytopharmaceuticalshas been examined by us. We undertake the following: a.
What are the best books on dosage form design?
Pharmaceutics: the science of dosage form design, 2nded. Churchill livingstone, Newyork: Harcourt publishers; 2002. p. 499-533. 4. Remington. The Science and Practice of Pharmacy, 21sted., vol.1, B.I. Publications Pvt. Ltd., Reprint; 2006. p. 282-772.
Does moisture in the formulation prevent complete drying and brittleness?
However, the small moisture in the formulations may prevent complete drying and brittleness.
How was the dose of the phytopharmaceutical selected?
The dose of the phytopharmaceutical was selected based upon reported topical dose from the literature. As compare with the conventional dosage form, in transdermal drug delivery system, drug permeates directly into the blood stream without undergoing first pass metabolism.